The Science


The following listing is a small subset of medical literature forms the bedrock of the Scientific reference and validation embedded into the Soza system.

The list can be considered a list of ingredients. The recipe we use is proprietary.


Adlin V, Channick BJ, Marks AD. (1969). Salivary sodium-potassium ratio and plasma renin activity in hypertension. Circulation. 39(5): 685-92.

Aghili (2013). Fixed Cut-Off for FEV1/FEV6 and FEV6 in Detection of Obstructive and Restrictive Patterns. Iran Red Crescent Med J. 2013 Feb;15(2):152-6.

Akselrod, (1988). Spectral analysis of fluctuations in cardiovascular parameters: a quantitative tool for the investigation of autonomic control. Trends Pharmacol Sci. 9: 6–9.

Allen, (2007). Photoplethysmography and its application in clinical physiological measurement. Physiol. Meas; 28: R1–R39

Allegaert (2014). Tympanic, infrared skin, and temporal artery scan thermometers compared with rectal measurement in children- a real-life assessment. Cur Ther Res 76; 34–38.

Alty SR, Angarita-Jaimes N, Millasseau SC and Chowienczyk PJ (2007). Predicting arterial stiffness from the digital volume pulse waveform IEEE Trans. Biomed. Eng. 54: 2268–75.

Anbar M, Gratt BM, Hong D. (1998). Thermology and facial telethermography. Part.I: history and technical review. Dentomaxillofac Radiol 27: 61-7.

Apa (2013). Clinical accuracy of tympanic thermometer and noncontact infrared skin thermometer in pediatric practice: an alternative for axillary digital thermometer. Pediatr Emerg Care. Sep;29(9):992-7.

Appel ML, Berger RD, Saul JP, et al. (1989). Beat to beat variability in cardiovascular variables: Noise or music? J Am Coll Cardiol 14: 1141.

Arnett (2007). Acid–base regulation of bone metabolism. Int Cong Ser 1297; 255–267.

Avolio (2008). Central aortic blood pressure and cardiovascular risk: a paradigm shift? Hypertension. Jun;51(6):1470-1471.


Barreiro & Perillo (2004). An approach to interpreting spirometry. Am Fam Physician. Mar 1;69(5):1107-14.

Bhat DS, Yajnik CS, Sayyad MG, Raut KN, Lubree HG, Rege SS, Chougule SD, Shetty PS, Yudkin JS, Kurpad AV. (2005). Body fat measurement in Indian men: comparison of three methods based on a two-compartment model. Int J Obes (Lond). 29(7): 842-8.

Bigger et al. (1992). Frequency Domain Measures of Heart Period Variability and Mortality After Myocardial Infarction. Circulation; 85:164-171

Bigger JT, Fleiss J, Steinman RC, et al. (1992). Frequency domain measures of heart period variability and mortality after myocardial infarction. Circulation 85: 164.

Busby DE, Bakris GL. (2004). Comparison of commonly used assays for the detection of microalbuminuria. J Clin Hypertens. 11(3): 8-12.

Butera G, et al. (2003). Heart rate variability in children with hypertrophic cardiomyopathy. Heart. February; 89(2):205-206.


Cacciatori V, et al. (2000). Power spectral analysis of heart rate in hypothyroidism. Eur J Endocrinol. 2000 Sep;143(3):327-33.

Camm AJ, Malik M et al. (1996). Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Circulation 93: 1043.

Casu (2005). Sympatho-vagal control of heart rate variability in patients treated with suppressive doses of L-thyroxine for thyroid cancer. Eur J Endocrinol. 2005 Jun;152(6):819-24.

Chan (1997). Accuracy, precision and user-acceptability of self blood glucose monitoring machines. Diabetes Res Clin Pract. 1997 May;36(2):91-104.

Ching (2014). Detection of airflow limitation using a handheld spirometer in a primary care setting. Respirology. Jul;19(5):689-93.

Cohen et al. (1999). Power Spectral Analysis of Heart Rate Variability in Psychiatry. Psychother Psychosom; 68:59–66

Cruickshank K, Riste L, Anderson SG, Wright JS, Dunn G, Gosling RG. (2002). Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function? Circulation 106: 2085–2090.

Coqueiro (2013). Validity of a Portable Glucose, Total Cholesterol, and Triglycerides Multi-Analyzer in Adults. Biol Res Nurs. 2013 Jul 19;16(3):288-294. (Coqueiro et al. 2013; Chan et al. 1997).


Davy JR. (1977). Medical Applications of Thermography. Phys Technolo 8: 54-60.

Devillé WL, Yzermans JC, van Duijn NP, Bezemer PD, van der Windt DA, Bouter LM. (2004). The urine dipstick test useful to rule out infections. A meta-analysis of the accuracy. BMC Urol. 2004 4: 4.

De Zeeuw D, Parving HH, Henning RH. (2006). Microalbuminuria as an early marker for cardiovascular disease. J Am Soc Nephrol. 17(8): 2100-5.

Dinneen SF, Gerstein HC. (1997). The association of microalbuminuria and mortality in non-insulin-dependent diabetes mellitus. A systematic overview. Arch Intern Med 157: 1413–8.

Di Tomasso D, Carnethon MR, Wright CM, Allison MA. (2010). The associations between visceral fat and calcified atherosclerosis are stronger in women than men. Atherosclerosis. 208(2): 531-6.


Erdmann (2006). – Microalbuminuria as a marker of cardiovascular risk in patients with type 2 diabetes. Int. J. Cardiol. Int. 107; 147 – 15.

Ewing DJ. (1991). Heart rate variability: An important new risk factor in patients following myocardial infarction. Clin Cardiol 14: 683.


Ferguson (2000). Office spirometry for lung health assessment in adults: a consensus statement from the National Lung Health Education Program. Chest. Apr;117(4):1146-61.


Ghosh S (1997) – Body Composition at the Bedside. Eur J Gastro Hepat Aug;9(8):783-8.

Gopaul NK, Manraj MD, Hebe A, Lee Kwai YS, Johnston A, Carrier MJ, Anggard EE. (2001). Oxidative stress could precede endothelial dysfunction and insulin resistance in Indian Mauritians with impaired glucose metabolism. Diabetologia 44: 706–712.

Goldstein (2010). Adrenal responses to stress. Cell Mol Neurobiol. Nov;30(8):1433-40.

Goldstein & Kopin (2007). Evolution of concepts of stress. Stress. Jun;10(2):109-20.


Higgins JL and Fronek A (1986). Photoplethysmographic evaluation of the relationship between skin reflectance and blood volume J. Biomed. Eng. 8: 130–6.


Ince (2004). – Lowering dietary protein to U.S. Recommended dietary allowance levels reduces urinary calcium excretion and bone resorption in young women. J Clin Endocrinol Metab. Aug;89(8):3801-7.


Kaminski G et al. (2012). The influence of subclinical hyperthyroidism on blood pressure, heart rate variability, and prevalence of arrhythmias. Thyroid. May;22(5):454-60.

Kass (2005). Ventricular Arterial Stiffening: Integrating the Pathophysiology. Hypertension, 46(1), 185-193.

Kleiger RE, Stein PK, Bigger JT Jr. (2005). Heart rate variability: measurement and clinical utility. Ann Noninvasive Electrocardiol. 10(1): 88-101.

Kopin (1995). Definitions of stress and sympathetic neuronal responses. Ann N Y Acad Sci. Dec 29;771:19-30.

Kyle UG, Bosaeus I, De Lorenzo AD, Deurenberg P, Elia M, Manuel Gómez J, Lilienthal Heitmann B, Kent-Smith L, Melchior JC, Pirlich M, Scharfetter H, M W J Schols A, Pichard C; ESPEN. (2004). Bioelectrical impedance analysis-part II: utilization in clinical practice. Clin Nutr. 23(6): 1430-53.


Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L, et al. (2001). Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 37: 1236–1241.

Laurent S, Katsahian S, Fassot C, Tropeano AI, Gautier I, Laloux B, Boutouyrie P. (2003). Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke 34: 1203–1206.

Leal AA, Faintuch J, Morais AA, Noe JA, Bertollo DM, Morais RC, Cabrini D. (2011) Bioimpedance analysis: should it be used in morbid obesity? Am J Hum Biol. 23(3): 420-2.

Lowe (2009). Non-invasive model-based estimation of aortic pulse pressure using suprasystolic brachial pressure waveforms. J Biomech. 2009 Sep 18;42(13):2111-5.


Maalouf (2007). – Low Urine pH- A Novel Feature of the Metabolic Syndrome. Clin J Am Soc Nephrol. Sep;2(5):883-8.

Malik et al. (1996). Heart Rate Variability Standards of Measurement, Physiological Interpretation, and Clinical Use. Circulation; 93: 1043-1065

Millasseau SC, Kelly RP, Ritter JM and Chowienczyk PJ (2002). Determination of age-related increases in large artery stiffness by digital pulse contour analysis. Clin. Sci. (Lond.) 103: 371–7.

Millasseau SC, Ritter JM, Takazawa K and Chowienczyk PJ (2006). Contour analysis of the photoplethysmographic pulse measured at the finger J. Hypertens. 24: 1449–56.

Mitchell (2011). Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility–Reykjavik study. Brain. Nov;134(Pt 11):3398-407.

Mogensen CE. (1984). Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N Engl J Med 310: 356–60.

Munir (2008). Peripheral Augmentation Index Defines the Relationship Between Central and Peripheral Pulse Pressure. Hypertension. Jan;51(1):112-8.


Nabili ST. (2009). Urinanalysis. 

Nakamura T, Tokunaga K, Shimomura I, Nishida M, Yoshida S, Kotani K, Islam AH, Keno Y, Kobatake T, Nagai Y, et al. (1994). Contribution of visceral fat accumulation to the development of coronary artery disease in non-obese men. Atherosclerosis. 107(2): 239-46.

Niedermeier W, Dreizen S, Stone RE, Spies TD. (1956). Sodium and potassium concentrations in the saliva of normotensive and hypertensive subjects. Oral Surg Oral Med Oral Pathol. 9(4): 426-31.

Nürnberger (2002). Augmentation index is associated with cardiovascular risk. J Hypertens. Dec;20(12):2407-14.


Parikh CR, Gyamlani GG, Carvounis CP. (2002). Screening for microalbuminuria simplified by urine specific gravity. Am J Nephrol. 22(4): 315-9.

Parving HH. (1996). Microalbuminuria in essential hypertension and diabetes mellitus. J Hypertens Suppl 14: S89–93.

Perez-Padilla (2013). Reliability of FEV1/FEV6 to diagnose airflow obstruction compared with FEV1/FVC: the PLATINO longitudinal study. PLoS One. 2013 Aug 1;8(8):e67960.

Prathibha (2013). Evaluation of Salivary Profile among Adult Type 2 Diabetes Mellitus Patients in South India. J Clin Diagn Res. Aug;7(8):1592-5.


Réka (2009). Preliminary results for use of Illness Marker in heart failure patients. ESPEN congress.

Roberts VC (1982). Photoplethysmography—fundamental aspects of the optical properties of blood in motion. Trans. Inst. 4: 101–6.

Roman (2007). Central pressure more strongly relates to vascular disease and outcome than does brachial pressure: the Strong Heart Study. Hypertension. Jul;50(1):197-203.


Safar & Jankowski (2009). Central blood pressure and hypertension: role in cardiovascular risk assessment. Clin Sci (Lond). 2009 Feb;116(4):273-82.

Shimizu & Kario (2008). Role of the augmentation index in hypertension. Ther Adv Cardiovasc Dis. Feb;2(1):25-35.


Tremblay (2012). Association between salivary pH and metabolic syndrome in women- a cross-sectional study. BMC Oral Health. Sep 8;12:40.


Valdespino-Trejo (2013) – Low albumin levels and high impedance ratio as risk factors for worsening kidney function during hospitalization of decompensated heart failure patients. Exp Clin Cardiol 18(2) 113-117

Vlachopoulos (2010). Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis. European Heart Journal, 31(15), 1865-1871.


Welch (2008). – Urine pH is an indicator of dietary acid-base load, fruit and vegetables and meat intakes- results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk population study. Br J Nutr. Jun;99(6):1335-43.

Wilkinson (2002). Increased central pulse pressure and augmentation index in subjects with hypercholesterolemia. J Am Coll Cardiol. Mar 20;39(6):1005-11.

Woods (2013). Noninvasive Temporal Artery Thermometry as an Alternative to Rectal Thermometry in Research Macaques. J Am Assoc Lab An Sci. 52(3); 295–300.

Wykretowicz (2007). Indices of vascular stiffness and wave reflection in relation to body mass index or body fat in healthy subjects. Clin Exp Pharmacol Physiol. Oct;34(10):1005-9.


Zamanzad B. (2009). Accuracy of dipstick urinalysis as a screening method for detection of glucose, protein, nitrites and blood. East Mediterr Health J. 15(5): 1323-8.

Zimlichman E, Lahad A, Aron-Maor A, Kanevsky A, Shoenfeld Y. (2005). Measurement of electrical skin impedance of dermal-visceral zones as a diagnostic tool for inner organ pathologies: a blinded preliminary evaluation of a new technique. Isr Med Assoc J. 7(10): 631-4.

Zipes DP. (1990). Influence of myocardial ischemia and infarction on autonomic innervation of heart. Circulation 82: 1095.

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